HLA-C and Epstein-Barr virus infection: Consistent with our GWAS results, the protein-coding variants with the largest effect sizes were in the MHC locus, where 148 MHC class I, 113 MHC class II, and 7 non-classical HLA protein-altering variants were significantly associated with EBV DNAemia (Fig. 3b), collectively emphasizing the role of heterogeneous antigen processing and presentation in controlling EBV infection and latent persistence.