Consistent with these findings in mouse LSCs, the PI3K inhibitor copanlisib also induced myeloid differentiation in the human AML cell lines MOLM14, NOMO1 and OCI-AML3, as evidenced by changes in morphology and increased expression of the monocytic markers CD15 and CD11b (Supplementary Figure 2). The gene discussed is PIK3CD; the disease is acute myeloid leukemia.