KMT2A and acute myeloid leukemia: Additionally, quantitative RT-PCR (qPCR) on LSC colonies at seven days after treatment with alpelisib or buparlisib revealed a decrease in the expression of HoxA9 and Meis1, which have been implicated as self-renewal genes in the pathogenesis of KMT2A-MLLT3 AML [33] (Figure 1F).