For example, in TREM2-related research, more studies should deeply analyze its signaling pathway and mechanism of action in neurodegenerative diseases such as Alzheimer’s disease, and explore the development of drugs targeting TREM2, including small molecule inhibitors or agonists, and TREM2-based immunomodulatory therapies, which are expected to provide new breakthroughs for the treatment of neurodegenerative diseases. This evidence concerns the gene TREM2 and early-onset autosomal dominant Alzheimer disease.