Variants of immune-related genes, such as TREM2, as well as the TREM2-APOE pathway, can drive transcriptional phenotypic changes in microglia, affecting their function and the pathogenesis of AD (Guerreiro et al., 2013; Krasemann et al., 2017; Ulrich et al., 2018; Parhizkar et al., 2019). This evidence concerns the gene APOE and Alzheimer disease.