Some articles revisit or reevaluate the amyloid hypothesis (the idea that the accumulation of amyloid-beta plaques in the brain is a central cause of AD) (Pimplikar, 2009; Armstrong, 2011), while others explore alternative or additional pathways, such as tau pathology, lipid processing, and immune dysfunction (Cao et al., 2018; Yamazaki et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.