CSF biomarkers revealed a hierarchical depletion of Aβ42 (AD: 370.7 ± 145.9 vs. HC: 910.8 ± 191.5 pg./mL, p < 0.001) and accumulation of tau (t-tau: AD>MCI > HC, p < 0.001). Here, MAPT is linked to Alzheimer disease.