In schizophrenia, meta-analyses consistently report elevated levels of inflammatory markers such as C-reactive protein (CRP), soluble IL-2 receptor (sIL-2R), and IL-6, suggesting immune dysregulation may contribute to neuro-progressive processes, including synaptic pruning deficits, microglial activation, and dopaminergic instability (17–19). This evidence concerns the gene CRP and schizophrenia.