IL27 and obesity due to melanocortin 4 receptor deficiency: The significant inverse correlation between IL-2 and BMI contrasts with findings in general populations, where obesity is typically associated with elevated proinflammatory cytokines (14, 15).But there was also a study found that individuals with obesity show significantly decreased levels of serum IL-27 (31).This discrepancy may reflect unique pathophysiological mechanisms in schizophrenia, potentially involving antipsychotic-induced immunomodulation.