2‐AAA treatment stimulated insulin secretion from BTC6 cells as well as isolated mouse and human islets.[19] Another study revealed that elevated levels of 2‐AAA correlated with obesity and impaired insulin signaling.[72] In this study, 2‐AAA treatment significantly promoted gluconeogenesis in primary mouse hepatocytes involved in increased expressions of Pck1 and amino acid metabolism genes through H2BK12Cr modification. Here, PCK1 is linked to obesity disorder.