In the genetic background of primary PNET patients, MEN1 is a commonly mutated gene, and most of them are germline deletion mutations.[73] We constructed a Men1‐deficient gene‐edited mice model of PNET spontaneous tumor, recapitulating human Men1‐associated PNETs.[29, 74] In this study, we performed mIHC comparisons utilizing pancreatic tissues from six genetically engineered mice with wild‐type mice, and the results showed that the primary tumors were found to be highly enriched in clear ACSS2 and FasL proteins (Figure 7D,E). The gene discussed is ACSS2; the disease is neoplasm.