Reports have shown that ACSS2 acts as a lactose coenzyme A synthase in combination with KAT2A as a lactosyltransferase for histone lactosylation and tumor immune evasion.[79] Herein, this study focuses on the function of ACSS2 in PNETs and reveals a novel mechanism by which it affects tumor biological behavior through histone acetylation modification. This evidence concerns the gene ACSS2 and neoplasm.