The staining with hematoxylin and eosin (H&E) and Safranin‐O and Fast Green (SO&FG) revealed significant disorganization and calcification of the NP matrix, accompanied by chondroid‐like proliferation and clustering of NP cells, especially in tissues from the severely degenerated group (Grade V) (Figure 1B).[33] Notably, the severe degeneration group exhibited low expression of the extracellular matrix protein collagen II, coupled with high expression of matrix metallopeptidase 3 (MMP3), which are hallmark features of intervertebral disc degeneration (Figure 1B,D,E). Here, MMP3 is linked to Intervertebral disk degeneration.