Moreover, the subgroup analysis indicated significant differences between the two groups for the country (origin of publication) (SMD = 1.87, 95% CI = [1.17, 2.56], I2 = 96.6%, p < 0.001), sampling time (SMD = 1.87, 95% CI = [1.17, 2.56], I2 = 96.6%, p = 0.010), and sample source (SMD = 1.87, 95% CI = [1.17, 2.56], I2 = 96.6%, p = 0.010).<h4>Conclusion</h4>The IL-1β, IL-6, and TNF-α levels are increased in individuals with epileptic seizures, which could serve as effective biomarkers for epileptogenesis. The gene discussed is IL1B; the disease is Seizure.