AD is a progressive and irreversible degenerative disease of the nervous system.The characteristic pathological changes in patients with AD includeneurofibrillary tangles formed by hyperphosphorylated tau protein and spotsformed by Aβ deposition [23], and changes in pathologic markers and brainstructural precede decline in cognitive function in patients with AD [24]. This evidence concerns the gene MAPT and neurodegenerative disease.