To date, several studies have demonstrated that immune evasion can promote the recurrence and aggressive progression of esophageal cancer through activation of the programmed death‐ligand 1 (PD‐L1)/programmed death receptor 1 (PD‐1) signaling pathway (Okadome et al. 2020; Ohigashi et al. 2005). Here, CD274 is linked to esophageal cancer.