However, in the brains of individuals who died with the primary tauopathies progressive supranuclear palsy (PSP) (McGeachan et al. 2025) and frontotemporal dementia caused by the MAPT 10+16 mutation (Dando et al. 2024), we did not observe increased microglial engulfment, and increased astrocytic engulfment was only observed in PSP. This evidence concerns the gene MAPT and progressive supranuclear palsy.