MAPT and Classical progressive supranuclear palsy: However, in the brains of individuals who died with the primary tauopathies progressive supranuclear palsy (PSP) (McGeachan et al. 2025) and frontotemporal dementia caused by the MAPT 10+16 mutation (Dando et al. 2024), we did not observe increased microglial engulfment, and increased astrocytic engulfment was only observed in PSP.