LDHB and neoplasm: In the tumour microenvironment, lactate dehydrogenase B (LDHB) critically regulates disulfidptosis in CD8+ T cells: SLC7A11-mediated cystine uptake induces disulfide stress, while LDHB interaction with G6PD depletes NADPH and drives disulfidptosis, leading to T cell exhaustion and compromised antitumour immunity via STAT3-dependent LDHB overexpression [34].These findings underscore organ-specific vulnerability to disulfidptosis, modulated by ubiquitination, organelle stress, and immune-editing pathways.