TP53 and neoplasm: For example, a low-grade, FIGO (International Federation of Gynecology and Obstetrics) 2009 stage IA tumor (initially low-risk) may be upgraded to high-risk if a TP53 (Tumor protein 53) mutation is found postoperatively, while high-intermediate risk tumors with cervical invasion may be downgraded if a POLE (Polymerase ε) mutation is identified [2].