Relative to ND, T2D trabeculae showed a significant decrease in tissue area labeled by phalloidin, a marker of myofilament F‐actin (ND: 33.1 ± 6.8%; T2D: 23.5 ± 2.4%, p = 0.02, Figure 3c), and vimentin antibody (ND: 9.3 ± 0.8%; T2D: 7.9 ± 0.3%, p = 0.01, Figure 3d), whereas no significant difference was observed between groups in the tissue area labeled by type I collagen antibody (ND: 9.2 ± 1.8%; T2D: 8.0 ± 1.0%, p = 0.24, Figure 3d). The gene discussed is VIM; the disease is type 2 diabetes mellitus.