GCG and obesity due to melanocortin 4 receptor deficiency: Interestingly, the ratio of GLP‐1 expressing cells to chromogranin A expressing cells was significantly higher in patients with T2D, but not in non‐T2D patients (Figure 6), suggesting that in addition to endocrine cell hyperplasia, obesity with T2D is associated with quantitatively abnormal differentiation patterns of the endocrine cells.