However, meta‐analyses suggest that although there is a trend for lower postprandial GLP‐1 levels in obesity as compared with normal weight controls, no significant differences are present in either basal or postprandial levels (Calanna et al., 2013; Knop et al., 2012; Nauck et al., 2011; Watkins et al., 2023). Here, GCG is linked to obesity due to melanocortin 4 receptor deficiency.