F12 and acute myeloid leukemia: Subsequent proliferation assays demonstrated that suppression of either MMP7 or F12 significantly reduced SKM-1 cell viability (MMP7 KD: 58 ± 5% reduction at 72 h; F12 KD: 52 ± 4% reduction at 72 h; both p < 0.001 vs control) (Fig. 6J and K), confirming their critical roles in AML cell proliferation.