Recent studies indicate that malignant tumors promote coagulation pathways by secreting procoagulants such as tissue factor (TF, encoded by the F3 gene), leading to a hypercoagulable state linked to VTE formation, localized hypoxia, and subsequent remodeling of the tumor microenvironment, which supports tumor progression and metastasis [11–13]. The gene discussed is TF; the disease is neoplasm.