Natural products such as sulforaphane, bleomycin, vitamin B5 (pantothenate), quercetin, salvianolic acid A, kaempferol, and apigenin have demonstrated the ability to inhibit PKM2 nuclear translocation, effectively suppressing tumor growth and inflammatory signaling in various cancer and immune cell contexts [9, 18, 24, 76, 139, 140, 160, 181, 188]. This evidence concerns the gene PKM and neoplasm.