Because this exceptional group of PWH presented a wide spectrum of comprehensively phenotyped motor and cognitive disorders, we were able to identify for the first time an inverse association between the severity of extrapyramidal motor dysfunction measurable by mUPDRS and the levels of IgG antibodies specifically against HIV Tat, thus suggesting the notion of protective effects of anti-Tat antibodies against dopaminergic neuronal deficits in older PWH. This evidence concerns the gene TAT and Cognitive impairment.