LDHB and neoplasm: The siRNA-based silencing of LDHB significantly reduced LDHB protein expression (Fig. S1A), resulting in decreased formation of colonies and tumor spheres, proliferation and cell viability in three PM cell lines with different LDHB basal protein levels, i.e., MSTO-211H, MESO4 and H2052 (Fig. S1B–E).