Beyond transcriptional control, lncRNAs modulate key signaling pathways involved in cancer, including the PI3K/AKT/mTOR, Wnt/β-catenin, NF-κB, and TGF-β pathways, which play crucial roles in tumor proliferation, angiogenesis, epithelial-to-mesenchymal transition (EMT), and immune evasion [39–42]. The gene discussed is NFKB1; the disease is cancer.