Preclinical studies show that Resveratrol, a potent sirtuin-1 activator, is a well-known anticancer drug, and it is reported to induce mitophagy through the MALAT1/miR-143-3p/RRM2 axis, effectively inhibiting cancer progression in hepatocellular carcinoma [100]. This evidence concerns the gene MALAT1 and hepatocellular carcinoma.