Among these, SHCBP1 emerged as a key candidate, acting as a SHC SH2-domain binding protein that regulates multiple signaling pathways, including FGF, NF-κB, MAPK/ERK, PI3K/AKT, TGF-β1/Smad, and Wnt/β-catenin, suggesting its crucial and consistent role in liver fibrosis pathogenesis [28]. The gene discussed is SHC1; the disease is Hepatic fibrosis.