Notably, immunohistochemistry, Masson’s trichrome staining, Western blot, and qRT-PCR analysis collectively demonstrated that MCM7 expression commenced increasing in S. japonicum-infected and CCl4-treated mouse livers at 4 weeks post-treatment and continued to rise up to 8 weeks, exhibiting a positive correlation with the progression of hepatic fibrosis (Figs. 1C, D, and S1D–H). Here, MCM7 is linked to Hepatic fibrosis.