CD8A and adenoma: As reported in Table 4, among patients naïve to medical therapy with fg‐SRLs at surgery, independent risk factors for the occurrence of post‐surgical SRL resistance were the adenoma invasive pattern (OR: 10.5, 95% IC: 3–35.9, p = .05), the absent or cytoplasmic expression of the SSTR2a (OR: 2, 95% IC: 1.2–3.4, p = .022), and a CD68+/CD8+ ratio higher than 4.7 (OR: 4.3, 95% IC: 1.4–12.9, p = .006).