In a cohort of 67 patients with acromegaly (naïve to medical therapy before surgery) we reported that the CD68+/CD8+ ratio was higher in somatotropinomas not responsive to post‐surgical SRLs together with the absent/cytoplasmic expression of the SSTR2A and the persistence of macroscopic adenoma tissue.28 The gene discussed is CD8A; the disease is growth hormone-producing pituitary gland neoplasm.