SOD1 and ischemia: To confirm this, we analyzed the antioxidant enzymatic activity at the end of ischemia (H0) and during the early phase of reperfusion (H1–H3): while superoxide dismutase (SOD) and peroxidase activities dropped dramatically at the end of ischemia (H0) in the vehicle group, GC7 pretreatment prevented this decrease (Fig. 1B).