Although our results in this study overall support a tumor suppressing role for PIWIL2 in colon tumorigenesis, there have been conflicting reports regarding the role of PIWIL2 in cancer (Lee et al., 2006; Lu et al., 2012; Wang et al., 2015a; Zeng et al., 2017; Eckstein et al., 2018; Meseure et al., 2020; Kishani Farahani et al., 2023; Shi et al., 2020). Here, PIWIL2 is linked to neoplasm.