Interestingly, PIWIL2 downregulation does not correlate with p53 status (Fig. 2D); however, PIWIL2 was significantly downregulated in adenocarcinomas compared to normal tissues, and even more downregulated in mucinous adenocarcinomas (Fig. 2E). This evidence concerns the gene PIWIL2 and colon mucinous adenocarcinoma.