Then, to examine whether PIWIL2's allelic losses are also accompanied with downregulation of PIWIL2 in colon cancer, we interrogated the COAD dataset of TCGA using UALCAN, to examine PIWIL2 mRNA expression stratified by normal versus: primary tumor; tumor stages; nodal metastasis; p53 status; histological subtype (adenocarcinoma, mucinous adenocarcinoma); microsatellite stability status; patient age; weight; race; and biological sex (Fig. 2A-J). Here, PIWIL2 is linked to malignant colon neoplasm.