Although Cxcr1 was demonstrated to play an essential role in regulating the function of Ly6C+ cDC2s during LPS‐induced ALI, it is acknowledged that the LPS model may not fully recapitulate the complexity of viral ARDS, such as COVID‐19, which is characterized by pulmonary edema, hyaline membrane formation, and capillary congestion and microthrombosis.[45, 46] Nonetheless, the LPS model remains highly relevant for investigating cytokine‐driven lung injury, a hallmark of sepsis/toxemia and ARDS triggered by severe systemic infections. Here, CXCR1 is linked to acute respiratory distress syndrome.