Inhibitors targeting DNA methyltransferase (DNMT) in gliomas and melanoma.[23, 28] enhancer of Zeste homolog 2 (EZH2) in lung cancers,[26] and lysine demethylase 5 (KDM5) in colorectal cancers[24] are known to restore STING expression. This evidence concerns the gene EZH2 and central nervous system cancer.