Branched‐chain α‐keto‐acid dehydrogenase kinase (BCKDK, also known as BDK) plays a pivotal regulatory role in the catabolic pathway of BCAAs by inhibiting the activity of the downstream branched‐chain α‐keto acid dehydrogenase (BCKDH) complex through phosphorylation of the E1‐α subunit at Ser293.[20] Previous studies have established a strong association between BCKDK and the progression of various cancers. This evidence concerns the gene BCKDK and cancer.