While BCKDK‐dependent apoptosis in TNBC relies on the terminal executioner caspase‐7,[47] we demonstrate that BCKDK targeting in RCC activates the mitochondrial apoptotic pathway, triggering cytochrome c release and subsequent activation of caspase‐9, which further activates the downstream executioner caspase‐3, ultimately inducing apoptosis. Here, BCKDK is linked to renal cell carcinoma.