Preliminary studies revealed that the BCKDK/exosomal‐miR‐125a‐5p/VE‐cadherin signaling axis mediates intercellular communication between HUVECs and RCC cells to regulate the vascular microenvironment.[24] However, our present study specifically focuses on BCKDK's protein kinase function, providing an in‐depth investigation into how its tumor‐associated overexpression mediates tumorigenesis and drug resistance through phosphorylation‐dependent regulation of downstream substrates. The gene discussed is WEE1; the disease is renal cell carcinoma.