Notably, our findings suggest that in RCC progression, the BCKDK/AKT/mTOR signaling axis‐mediated pro‐tumor mechanisms represent a molecular pathway distinct from the previously reported BCKDK‐regulated exosomal miR‐125a‐5p/VE‐cadherin axis that activates angiogenesis to facilitate tumor metastasis. This evidence concerns the gene CDH5 and renal cell carcinoma.