CDH5 and renal cell carcinoma: Preliminary studies revealed that the BCKDK/exosomal‐miR‐125a‐5p/VE‐cadherin signaling axis mediates intercellular communication between HUVECs and RCC cells to regulate the vascular microenvironment.[24] However, our present study specifically focuses on BCKDK's protein kinase function, providing an in‐depth investigation into how its tumor‐associated overexpression mediates tumorigenesis and drug resistance through phosphorylation‐dependent regulation of downstream substrates.