GPX4 and cholangiocarcinoma: The findings showed that NCOA4 downregual promoted cell proliferation,migration and invasive in RBE and HCCC-9810 via inhibiting ferroptosis,proving that NCOA4 is a novel gene linked with CCA.These outcomes imply the regulatory effects of NCOA4 on GPX4 protein and its contribution to malignant progression in CCA, which could provide a potential therapeutic target for CCA.