LRRK2 and Parkinson disease: The kinases included 1) leucine-rich repeat kinase 2 (LRRK2), a multifunctional enzyme (1194 residues) and driver of heritable Parkinson’s disease [27]; and 2) a variant of phosphoinositide 3-kinase α (PI3Kα), a lipid kinase of similar size (1096 residues) but distinct fold, mediating cellular growth signals in human cancers [28] (Table 1 and S1 Fig).