GCG and diabetes mellitus: Diabetes is a leading cause of blindness in the US, and more advanced DR at diagnosis substantially increases the risk of blindness.29,30,31 Untreated PDR or DME also poses higher risks.32,33 Improving HbA1c is the key factor in delaying DR progression and preventing sight-threatening complications.23,34 With advances in DR screening reducing visual impairment, our findings suggest that GLP-1 RAs could further contribute to these positive patterns.35