In the preexisting DR subgroup, the severity of diabetic retinopathy was similar between individuals with and without GLP-1 RA prescriptions at baseline after PSM (severe: 1537 [4.7%] vs 1569 [4.8%]; standard mean difference, 0.001) (eTable 4 in Supplement 1). The gene discussed is GLP1R; the disease is diabetic retinopathy.