In contrast to the commonly accepted models and evidence associating higher levels of pro-inflammatory cytokines, genotoxicity, and cytotoxicity with severe COVID-19 [78, 104, 105], recent studies show that mild cases may exhibit unexpectedly higher levels of IL-1β, IL-18, IL-6, MCP-1, and IL-4, as well as specific IgM and IgG anti-SARS-CoV-2 antibodies, compared to severe cases [106, 107]. The gene discussed is IL1B; the disease is COVID-19.