CD274 and neoplasm: Although previous studies have demonstrated the effectiveness of photothermal therapy (PTT) combined with anti‐PD‐1/PD‐L1 therapy, most regimens rely on high temperatures (> 50 °C) to induce ICD.[63, 64] However, excessive heat can trigger non‐specific inflammatory responses and damage healthy tissues.[65] Furthermore, when anti‐tumor immune peptides and photothermal agents are delivered via different carriers, their synergistic effects on heterogeneous tumor cell populations may diminish due to asynchronous drug distribution.