Its role in activating the NLRP3 inflammasome has been implicated in the pathogenesis of conditions such as pulmonary fibrosis (156), diabetic cardiomyopathy (157), asthma (158), radiation-induced brain injury (RIBI) (159), and preterm premature rupture of membranes (PPROM) (160). The gene discussed is NLRP3; the disease is pulmonary fibrosis.