In HIV infections, GBP5 inhibits replication by suppressing furin-mediated proteolytic processing of the viral gp160 Env precursor into functional gp120/gp41 subunits, compromising Env maturation and reducing virion infectivity, thereby establishing its potential as an anti-HIV target (8, 24, 35). The gene discussed is ERVW-1; the disease is HIV infectious disease.