In the context of diabetic cardiomyopathy, bone morphogenetic protein-7 (BMP-7) alleviated inflammation-induced pyroptosis by inhibiting the TLR4-NLRP3 complex, which is activated by GBP5 and NIMA-related kinase 7 (Nek7). The gene discussed is TLR4; the disease is diabetic cardiomyopathy.