Located in the ANKRD55 gene,[26] which encodes an ankyrin repeat domain‐containing protein involved in immune regulation,[24] rs11077054 has previously been implicated in multiple immune‐mediated conditions—pathways that are increasingly recognized as contributors to AD pathogenesis.[27, 28] Our analyses revealed that rs11077054 is significantly associated with ROI 63 (frontal lobe) and total deep white matter hyperintensity (WMH) volume, both of which are key neuroimaging markers linked to executive dysfunction and cerebrovascular pathology in AD. This evidence concerns the gene ANKRD55 and Alzheimer disease.