FGF21 and amyotrophic lateral sclerosis: In the Pooled Resource Open-Access ALS Clinical Trials database (PRO-ACT), patients with a BMI between 25 – 30 kg/m2 (similar to the mean value of 29.2 kg/m2 in the high FGF21 subset reported here) had a 35% reduced risk of dying compared to patients with BMI < 25 kg/m2 (the low FGF21 group in our study had a mean BMI of 22.6 kg/m2) [59].