Consistently, the results showed a significant increase in protein levels of ATG4B and γ‐H2AX in mouse AML cells induced by MLLT3‐KMT2A fusion gene (t(9;11)(p21.3;q23.3)) overexpression, accompanied by a corresponding decrease in PRMT1 protein levels (Figure 6B). The gene discussed is MLLT3; the disease is acute myeloid leukemia.