MRGPRF and melanoma: In melanoma cells, an elevated level of MRGPRF has been shown to suppress proliferation and migration in vitro, as well as inhibit the growth and metastasis of melanoma xenografts in vivo, possibly by reducing activation of the PI3K/AKT pathway.[19] Mechanistically, MRGPRF interacts with the N‐terminal domain (residues 1–216) of p110γ, directly competing with p101 for binding at this site.