Additionally, USP45 and MRGPRF negatively regulate MYC and Snail expression in melanoma cells, possibly because they are melanoma suppressors, while MYC and Snail serve as oncogenes in melanoma.[42, 43] Alternatively, the regulation of MYC and Snail by USP45 may involve other factors that are absent in melanoma cells. This evidence concerns the gene SNAI1 and melanoma.