MYC and cancer: To investigate whether the antimelanoma effect of USP45 is mediated by additional substrates, we examined its influence on the expression of MYC and Snail, which are known substrates of USP45 and are stabilized by it in other cancers.[40, 41] Western blot analysis revealed that MYC and Snail expressions were suppressed by USP45 overexpression in A375 cells, whereas their levels were elevated in USP45‐deficient SK‐MEL‐2 cells (Figure S5A, Supporting Information).