USP45 and melanoma: For example, USP45 has been shown to promote stemness and drug resistance in cervical cancer cells by stabilizing the oncogenic MYC.[41] Similarly, USP45 functions as an oncogene in ovarian cancer cells, potentially through the stabilization of Snail.[40] By contrast, our study demonstrates that USP45 stabilizes MRGPRF, which acts as a melanoma suppressor.