Curiously, in different situations, USP45 forms a connection with ERCC1 through its brief acidic motif that is positioned outside of the catalytic domain.[44] Similarly, the binding of USP45 to MYC in cervical cancer cells is also independent of its catalytic domain.[41] The specific domain responsible for the USP45–Snail interaction remains unknown. This evidence concerns the gene MYC and cervical cancer.