To answer this question, we employed GW4869 – a neutral sphingomyelinase inhibitor known to inhibit EVs secretion and vesicle trafficking in vivo.[31] Our previous reports have shown that lipid‐coated polyacylic acid/calcium phosphate nanoparticles (PAA/CaP NPs), a new dual pH‐responsive drug delivery system for targeted cancer chemotherapy,[32] were used as a GW4869 delivery vehicles for cancer (Figure3a). The gene discussed is SMPD2; the disease is cancer.