MiR‐485‐3p is packaged into extracellular vesicles and transferred from tumor cells to cardiomyocytes, where it downregulates the expression of peroxisome proliferator‐activated receptor gamma coactivator‐1 alpha (PGC‐1α), a critical regulator of the mitochondria and energy metabolism homeostasis. This evidence concerns the gene PPARGC1A and neoplasm.