Interestingly, in line with our findings, a separate study showed that miR‐485‐3p suppresses breast cancer cell metastasis by inhibiting PGC‐1α expression.[49] It is known that heart specific PGC‐1α knock‐out induces metabolic, functional and structural abnormalities leading to dilating cardiomyopathy and heart failure.[50] Notably, we provide the first evidence that miR‐485‐3p levels are elevated in the plasma of CC10‐KRASG12D cancer model mice, and that tumor‐derived extracellular vesicles containing miR‐485‐3p exacerbate ischemia/reperfusion‐induced cardiac injury. This evidence concerns the gene PPARGC1A and breast cancer.