To clarify whether the elevated miR‐485‐3p levels resulted from increased EVs secretion by tumor tissues under I/R conditions or enhanced cardiac EVs uptake post‐I/R, we measured the expression of Ras‐associated protein 27a (Rab27a), a protein critical for regulating EVs release from organ tissue.[35] The results revealed significantly higher Rab27a expression in lung tumor tissues of CC10‐KRASG12D mice compared to WT lung tissues under both sham and I/R conditions. This evidence concerns the gene RAB27A and neoplasm.