Reportedly, enhanced activation of the EGF receptor (EGFR) is associated with the development and progression of renal fibrosis, and genetic or pharmacological blockade of EGFR can inhibit this condition.[22] To explore whether EGFR might be a target of Glce protein, we conducted a surface plasmon resonance (SPR) experiment and found that Glce protein had a strong binding interaction with the intracellular domain of EGFR in vitro but did not bind to its extracellular domain. Here, EGFR is linked to renal fibrosis.