MAPK8 and obesity due to melanocortin 4 receptor deficiency: Previous studies have suggested that the JNK‐AP1 pathway plays important roles in obesity by influencing transcription or epigenetic pathways, promoting inflammation, affecting adipose growth and function, and regulating metabolic homeostasis and inflammatory cytokine expression, thereby impacting obesity‐related metabolic disturbances.[40, 41] The AP‐1 signaling pathway plays an important role in hepatic steatosis[42] and is involved in regulating adipose tissue function.