The PDX and CDX models revealed that a high‐PA diet promoted HCC progression, but after treatment with the HDAC8 inhibitor PCI‐34051, the tumors shrank significantly, and the extent of shrinkage was greater than that in the normal diet‐fed group (Figures6a–h and S10d—g, Supporting Information). This evidence concerns the gene HDAC8 and hepatocellular carcinoma.