Excessive SFA intake accelerates hepatic cholesterol synthesis, leading to elevated cholesterol levels.[29] Excess cholesterol accumulation in arterial walls increases cardiovascular disease risk.[30] Furthermore, SFAs impair insulin signaling pathways, reduce cellular insulin sensitivity, and disrupt glucose metabolism, potentially contributing to hyperglycemia and diabetes.[31] In the context of oncology research, while most studies have shown that SFAs have protumorigenic effects, there are some reports of environmentally dependent anticancer effects of SFAs. The gene discussed is INS; the disease is diabetes mellitus.