The upregulation of ICAM‐1 expression in ECs is commonly observed in inflamed blood vessels and has also been reported in the IH models in previous studies.[65, 66, 67] Reportedly, blood vessels in inflammatory conditions downregulate VE‐cadherin expression in ECs, which is related to vascular permeability.[63, 65, 68] It was also documented that PECAM‐1 on ECs is delocalized into the surface of the ECs in the presence of inflammatory cytokine.[69]. This evidence concerns the gene CDH5 and isolated hemihyperplasia.