In addition, we simplified the inflammatory cytokines TNF‐α and IL‐1β, because TNF‐α and IL‐1β activate NF‐κB, which transcriptionally induces the production of inflammatory cytokines including IL‐6, IL‐8, and MCP‐1.[38, 57] Therefore, secretion of various types of inflammatory cytokines was observed in the IH model (Figure 7). This evidence concerns the gene IL1B and isolated hemihyperplasia.