In the secretome analysis (Figure 7), MCP‐1 and IL‐8, which were elevated under all conditions, were presumed to be associated with a lack of nitric oxide production due to the absence of shear stress.[83, 84, 85] Notably, MCP‐1 in an arterial model with perfusion was measured to be relatively low even under disease conditions in our previous study.[17] EGF was highest in the control group and decreased in the IH condition, but there was a tendency for a slight increase under drug conditions, although no statistical significance was observed. Here, EGF is linked to isolated hemihyperplasia.