Since diuretics such as hydrochlorothiazide are a known cause of hyponatraemia, especially in older patients with a history of diuretic-induced hyponatraemia, it would be advisable to avoid them.10 Instead, alternative antihypertensive agents such as calcium channel blockers, angiotensin-converting enzyme inhibitors or angiotensin II receptor blockers can be used. This evidence concerns the gene ACE and Hyponatremia.