Among them, mice with a deficiency for Fgfr1 (Zhou et al., 2000), Fgfr2 (Eswarakumar et al., 2004), Kif3a (Liu et al., 2014), Kras (Hernandez-Porras et al., 2014), Ptch1 (Sweet et al., 1996), Rreb1 (Kent et al., 2020), Sos1 (Chen et al., 2010), and Tfap2a (Nelson and Williams, 2004) show excessive proliferation during midfacial development, resulting in hypertelorism, suggesting that mimics of miR-383-3p and miR-6951-3p activate cell proliferation through suppression of these genes. Here, RREB1 is linked to Hypertelorism.