It suppresses the epithelial-mesenchymal transition through the SHH-GLI family zinc finger 1 (GLI1) pathway in hepatocellular carcinoma (Chen et al., 2017) and through downregulation of the methylcrotonyl-CoA carboxylase subunit 1 (MCCC1) expression in malignant melanoma (Zhang et al., 2019) and gastric cancer (Huang et al., 2015). Here, SHH is linked to hepatocellular carcinoma.