Previous studies usually focused on traditional indicators such as LDL, but they reflected only the promoting effects of atherosclerosis, and the effects of each component of the lipid profile on atherosclerosis were different, whereas APOB/APOA1, as a novel lipid parameter, took into account both promoting and inhibiting effects of atherosclerosis in the lipid profile and better reflected the trend of the effects of the lipid profile on atherosclerosis. The gene discussed is APOA1; the disease is atherosclerosis.