It has also been suggested that an elevated APOB/APOA1 ratio in patients with metabolic syndrome independently predicts the risk of aortic valve calcification, even when LDL is normal [33], which suggested the combination of APOB/APOA1 with hypertension, diabetes, and hyperlipidemia is a valid predictor of CAVD. Here, APOA1 is linked to congenital bilateral aplasia of vas deferens from CFTR mutation.