Similarly, an analysis of CRLF2 expression in 212 pediatric T-ALL patients from the Italian and German AIEOP-BFM ALL 2000 cohort revealed that 17 out of 120 Italian patients (14.2 %) had CRLF2 mRNA expression levels five times higher than the median [76]. This evidence concerns the gene CRLF2 and acute lymphoblastic leukemia.