CRLF2 and precursor B-cell acute lymphoblastic leukemia: RNA sequencing (RNA-seq) and quantitative PCR (qPCR) analyses of the xenograft tumors confirmed the expression of mTOR-regulated genes in primary CRLF2 B-ALL cells [88], substantiating the involvement of the PI3K/mTOR pathway in TSLP/TSLPR-mediated leukemia proliferation.