High expression levels of CRLF2 in both B-cell acute lymphoblastic leukemia (B-ALL) [[62], [63], [64], [65], [66], [67]] and T-cell acute lymphoblastic leukemia (T-ALL) [[73], [74], [75], [76]] are often correlated with poor prognosis and resistance to treatment. Here, CRLF2 is linked to acute lymphoblastic leukemia.