In adult patients with B-cell precursor acute lymphoblastic leukemia, high CRLF2 expression was also associated with higher white blood cell (WBC) counts, the presence of P2RY8-CRLF2 fusion, and IKZF1 deletions (IKZF1del) [65]. Here, CRLF2 is linked to precursor B-cell acute lymphoblastic leukemia.