Notably, our findings included 9 novel candidate risk loci for ADRD, including KCTD13, IGIP, HINT1, SH3TC2, FAM53B, TPM1, IL34, ACE and SSH2. In addition to these novel findings, we replicated two previously established AD loci—TNIP1 and SHARPIN [15,27]Our findings advance the catalog of ADRD-associated genetic variants and provide insights into the biological overlap between hippocampal volume and dementia risk, thereby supporting the use of imaging endophenotypes in genetic studies of neurodegenerative disease. This evidence concerns the gene ACE and neurodegenerative disease.