CD4 and neoplasm: As the tumor grows and develops, it can stimulate and induce the proliferation of CD8+ T lymphocytes, and the increase of CD8+ T lymphocytes can promote the growth of tumor cells to a certain extent, increase the risk of metastasis and recurrence, and is not conducive to the prognosis (60), and most patients exhibit a decrease in CD3+ and CD4+, leading to an imbalance of CD4+/CD8+ and a predominance of cell-mediated immune negative effects (61).