According to the GSEA results, in T2DM, apart from Central memory CD8 T cells, Activated CD4 T cells, Type 1 T helper cells, Type 2 T helper cells, and Plasmacytoid dendritic cells, no other immunocytes showed a significant difference in their number between the two groups (Figures 8A, C). Here, CD8A is linked to type 2 diabetes mellitus.